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Skeletal muscle abnormalities associated with occupational exposure to mercury vapours

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dc.contributor.authorNadorfy-Lopez, E.es
dc.contributor.authorTorres, S.H.es
dc.contributor.authorFinol, H.
dc.contributor.authorMendez, M.
dc.contributor.authorBello, B.
dc.date.accessioned2011-02-22T11:21:53Z
dc.date.available2011-02-22T11:21:53Z
dc.date.issued2000
dc.description.abstractThere is scarce information on the possible effects of chronic exposure to mercury on skeletal muscle. Dental personnel are frequently exposed to inhalation of metallic mercury vapours. The skeletal muscle of five technicians and one dentist (females, age 36-55) was studied. All of them presented symptoms of chronic mercury poisoning. Needle biopsy was taken from the quadriceps femoris muscle and samples were prepared for light microscope histochemistry and for transmission electron microscopy. Selective atrophy of type IIB muscle fibres was found in patients, and in one of them there was fibre grouping. Most of the muscles showed increased fibre area per capillary. Atrophy was confirmed by the ultrastructural study, demonstrating increase of intermyofibrillar spaces, loss of myofibrils or complete disappearance in some fibres, and sarcolemmal folding. Splitting of the fibres was also found. Some capillaries were altered, showing endothelial infoldings into the lumen, thickened basement membrane and partial or total occlusion. The alterations found in muscle may be secondary to nerve damage, to ischemia caused by capillary lesion andlor to a direct effect of mercury on muscle fibre proteins.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19334
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMercury toxicityes
dc.subjectMuscle fibre typeses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleSkeletal muscle abnormalities associated with occupational exposure to mercury vapourses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.15, nº 3 (2000)