Publication: Angiogenesis in the central nervous
system: a role for vascular endothelial
growth factor/vascular permeability factor and
tenascin-C. Common molecular effectors in cerebral
neoplastic and non-neoplastic “angiogenic diseases”
Authors
Zagzag, D. ; Capo, V.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Human pathological conditions of the central
nervous system (CNS) associated with angiogenesis (i.e.
neovascularization) include neoplastic, as well as
infectious, ischemic, and traumatic processes.
Upregulation of vascular endothelial growth
factor/vascular permeability factor (VEGF/VPF) and
tenascin-C (TN-C) is spatially and temporally related to
neovascularization. Spatially, VEGF/VPF and TN-C are
both found at the site of neovascularization, but they are
not detected in areas of normal brain or in areas without
neovascularization. Te m p o r a l l y, VEGF/VPF and TN-C
are found at the peak of angiogenesis and are not
detected when angiogenesis had ceased.
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Citation
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