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CD28 biomarker quantification and expression level profiles in CD4+ T-lymphocytes in solid organ transplantation

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dc.contributor.authorBoix, Francisco
dc.contributor.authorBolarín, José Miguel
dc.contributor.authorMrowiec, Anna
dc.contributor.authorEguía, Jorge
dc.contributor.authorGonzález Martínez, Gema
dc.contributor.authorPeña, Jesús de la
dc.contributor.authorGalían, José A.
dc.contributor.authorAlfaro, Rafael
dc.contributor.authorMoya Quiles, María R.
dc.contributor.authorCampillo, José Antonio
dc.contributor.authorRamírez, Pablo
dc.contributor.authorGarcía Alonso, Ana
dc.contributor.authorPons, José A.
dc.contributor.authorSánchez Bueno, Francisco
dc.contributor.authorMinguela, Alfredo
dc.contributor.authorLlorente, Santiago
dc.contributor.authorMuro, Manuel
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-11T11:36:38Z
dc.date.available2024-07-11T11:36:38Z
dc.date.issued2017-06
dc.description© 2017 Elsevier B.V. This document is the Published version of a Published Work that appeared in final form in Transplant Immunology. To access the final edited and published work see https://doi.org/10.1016/j.trim.2017.04.001
dc.description.abstractThe introduction of anti-calcineurin-based therapies has led to an increase in the one-year survival as well as graft function rates in patients undergoing solid organ transplantation (SOT). Nonetheless, early cellular acute rejection (EAR) incidence still remains a major challenge that irrevocably heads to poor outcomes. The mechanisms underlying CD4 T cell activation in SOT are still under research. In this sense, CD28 co-stimulatory molecule plays a pivotal role triggering CD4 T cell activation as well as survival maintenance. Previous own studies stated the role that CD4+ CD28+ circulating T lymphocytes plays before and during EAR episodes. We assessed the percentage as well as the absolute number of CD28 molecules on CD4+ T cells as predictive surrogate biomarker of EAR in a prospective cohort of liver and kidney transplant recipients. Quantitative analysis of CD28 was carried out on whole peripheral blood samples by flow cytometry. Decreased pre-transplant expression of CD28 was associated with EAR in both study groups. Furthermore, the expression of CD28 within the rejected group, experimented an up-regulation upon transplantation. These preliminary results suggest that patients undergoing liver or kidney transplant can be stratified at high risk of EAR according to their CD28 molecule expression on peripheral CD4+ T lymphocytes.es
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dc.format.extent9es
dc.identifier.citationTransplant Immunology, 2017, Vol. 42, pp. 9-17
dc.identifier.doihttps://doi.org/10.1016/j.trim.2017.04.001
dc.identifier.issnPrint: 0966-3274
dc.identifier.issnElectronic: 1878-5492
dc.identifier.urihttp://hdl.handle.net/10201/143015
dc.languageenges
dc.publisherElsevier
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S096632741630168X?via%3Dihub
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCD4 T lymphocyteses
dc.subjectCD28es
dc.subjectEarly acute rejectiones
dc.subjectLiver transplantationes
dc.subjectKidney transplantationes
dc.titleCD28 biomarker quantification and expression level profiles in CD4+ T-lymphocytes in solid organ transplantationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoveryb83b4b59-2d61-40f0-9108-5c6a6d158295
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