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Relationship between non-TRU lung adenocarcinomas and bronchiolar metaplasia - potential implication in their histogenesis -

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dc.contributor.authorOkudela, Koji
dc.contributor.authorKojima, Yoko
dc.contributor.authorMatsumura, Mai
dc.contributor.authorArai, Hiromasa
dc.contributor.authorUmeda, Shigeaki
dc.contributor.authorTateishi, Yoko
dc.contributor.authorMitsui, Hideaki
dc.contributor.authorSuzuki, Takehisa
dc.contributor.authorTajiri, Michihiko
dc.contributor.authorOgura, Takashi
dc.contributor.authorOhashi, Kenichi
dc.date.accessioned2022-04-05T11:06:27Z
dc.date.available2022-04-05T11:06:27Z
dc.date.issued2018
dc.description.abstractLung adenocarcinomas (ADCs) have been roughly divided into two groups: the terminal respiratory unit (TRU) type and non-TRU type. These ADCs appear to develop through exclusive carcinogenetic pathways because of differences in their cellular morphologies and the profiles of protein expression and genetic alterations. The TRU type develops from atypical adenomatous hyperplasia as a precursor. On the other hand, the histogenesis of the non-TRU type has not yet been defined in detail. We herein investigated histopathological changes in the non-tumor lung tissues of patients with non-TRU-type ADCs in order to define their potential histogenesis. The non-TRU type preferentially occurs in patients with interstitial pneumonia, in whom tumors are located in honeycomb lesions and are associated with bronchiolar metaplasia (BM). Among patients without interstitial pneumonia, non-tumor lung tissues from non-TRU-type ADCs were often affected by multiple BM. In these cases, tumors often were associated with BM. Metaplastic cells adjacent to non-TRU-type ADCs ectopically expressed HNF-4α, a marker for non-TRU-type ADCs. These results suggest that the non-TRU type develops through distinct histogenesis, in which BM is implicated.es
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dc.format.extent10es
dc.identifier.citationHistology and Histopathology, Vol.33, nº3, (2018)
dc.identifier.doiDOI: 10.14670/HH-11-935
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/118735
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNon-TRU-type lung adenocarcinomases
dc.subjectBronchiolar surface epithelial subtypees
dc.subjectBronchiolar metaplasiaes
dc.subjectHistogenesises
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleRelationship between non-TRU lung adenocarcinomas and bronchiolar metaplasia - potential implication in their histogenesis -es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.33, nº3 (2018)