Long-term social isolation in the adulthood results in CA1 shrinkage and cognitive impairment

Pereda-Pérez, Inmaculada; Baño-Otalora, Beatriz; Madrid, Juan Antonio; Rol, María Ángeles; Venero, Cesar; Popovic, Natalija; Popovic Popovic, Miroljub

Publication:
Long-term social isolation in the adulthood results in CA1 shrinkage and cognitive impairment

dc.contributor.author	Pereda-Pérez, Inmaculada
dc.contributor.author	Baño-Otalora, Beatriz
dc.contributor.author	Madrid, Juan Antonio
dc.contributor.author	Rol, María Ángeles
dc.contributor.author	Venero, Cesar
dc.contributor.author	Popovic, Natalija
dc.contributor.author	Popovic Popovic, Miroljub
dc.contributor.department	Anatomía Humana y Psicobiología
dc.date.accessioned	2025-04-14T09:11:29Z
dc.date.available	2025-04-14T09:11:29Z
dc.date.issued	2013-07-15
dc.description	© 2013, Elsevier. This document is the Published version of a Published Work that appeared in final form in Neurobiology of Learning and Memory. To access the final edited and published work see https://doi.org/10.1016/j.nlm.2013.07.004
dc.description.abstract	Social isolation in adulthood is a psychosocial stressor that can result in endocrinological and behavioral alterations in different species. In rodents, controversial results have been obtained in fear conditioning after social isolation at adulthood, while neural substrates underlying these differences are largely unknown. Neural cell adhesion molecule (NCAM) and its polysialylated form (PSA-NCAM) are prominent modulators of synaptic plasticity underlying memory processes in many tasks, including fear conditioning. In this study, we used adult female Octodon degus to investigate the effects of long-term social isolation on contextual and cued fear conditioning, and the possible modulation of the synaptic levels of NCAM and PSA-NCAM in the hippocampus. After 6½ months of social isolation, adult female degus showed a normal auditory-cued fear memory, but a deficit in contextual fear memory, a hippocampal dependent task. Subsequently, we observed reduced hippocampal synaptic levels of PSA-NCAM in isolated compared to grouped-housed female degus. No significant differences were found between experimental groups in hippocampal levels of the three main isoforms of NCAM (NCAM180, NCAM140 and NCAM120). Interestingly, social isolation reduced the volume of the hippocampal CA1 subfield, without affecting the volume of the CA3 subregion or the total hippocampus. Moreover, attenuated body weight gain and reduced number of granulocytes were detected in isolated animals. Our findings indicate for the first time, that long-term social isolation of adult female animals induces a specific shrinkage of CA1 and a decrease in synaptic levels of PSA-NCAM in the hippocampus. These effects may be related to the deficit in contextual fear memory observed in isolated female degus.	es
dc.format	application/pdf	es
dc.format.extent	9	es
dc.identifier.citation	Neurobiology of Learning and Memory 106 (2013) 31–39
dc.identifier.doi	https://doi.org/10.1016/j.nlm.2013.07.004
dc.identifier.issn	Print: 1074-7427
dc.identifier.issn	Electronic: 1095-9564
dc.identifier.uri	http://hdl.handle.net/10201/153343
dc.language	eng	es
dc.publisher	Elsevier
dc.relation	This work was supported by grants from the Spanish Ministry of Science and Technology (MCYT) (SAF2009-09129 to C.V.), by the Instituto de Salud Carlos III (RETICEF, RD06/0013; RETICEF, RD06/0013/0019 and RD12/ 0043/0011 to J.A.M., and RD06/0013/1027 to C.V); and by the Ministry of Science and Innovation (BFU 2010-21945-CO1, including FEDER cofounding to J.A.M.). I.P.P. is recipient of a PhD fellowship from the UNED.	es
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S1074742713001172?via%3Dihub	es
dc.rights.accessRights	info:eu-repo/semantics/restrictedAccess
dc.subject	Cortisol	es
dc.subject	Fear conditioning	es
dc.subject	Hippocampus	es
dc.subject	NCAM	es
dc.subject	Octodon degus; PSA-NCAM; Social isolation.	es
dc.subject	PSA-NCAM	es
dc.subject	Social isolation	es
dc.subject.other	CDU::6 - Ciencias aplicadas	es
dc.title	Long-term social isolation in the adulthood results in CA1 shrinkage and cognitive impairment	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
relation.isAuthorOfPublication	dc3015b4-805d-4b6e-a49f-f2d73bb3c2b2
relation.isAuthorOfPublication	43b53091-f5bf-4b46-b164-88d2a3670e2f
relation.isAuthorOfPublication.latestForDiscovery	dc3015b4-805d-4b6e-a49f-f2d73bb3c2b2