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Study of the link between neuronal death, glial response, and MAPK pathway in old parkinsonian mice

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dc.contributor.authorCuenca-Bermejo L,
dc.contributor.authorGallo-Soljancic P,
dc.contributor.authorSanchez-Rodrigo C,
dc.contributor.authorIzura V,
dc.contributor.authorSteinbusch HWM,
dc.contributor.authorFernandez-Villalba E,
dc.contributor.authorHerrero MT
dc.contributor.authorCuenca Bermejo, Lorena
dc.contributor.authorGallo-Soljancic, Pablo
dc.contributor.authorSanchez-Rodrigo, Consuelo
dc.contributor.authorIzura, Virginia
dc.contributor.authorSteinbusch, Harry W. M.
dc.contributor.authorFernández Villalba, Emiliano
dc.contributor.authorHerrero Ezquerro, María Trinidad
dc.contributor.authorGil Martínez, Ana Luisa
dc.contributor.departmentMedicina Interna
dc.contributor.otherFacultad de Medicina
dc.date.accessioned2026-01-08T12:38:20Z
dc.date.available2026-01-08T12:38:20Z
dc.date.copyright© 2020 Gil-Martinez, Cuenca-Bermejo, Gallo-Soljancic, Sanchez-Rodrigo, Izura, Steinbusch, Fernandez-Villalba and Herrero
dc.date.issued2020-07-29
dc.description.abstractParkinson's disease (PD) is described as an age-related neurodegenerative disorder. However, the vast majority of research is carried out using experimental models of young animals lacking the implications of the decline processes associated with aging. It has been suggested that several molecular pathways are involved in the perpetuation of the degeneration and the neuroinflammation in PD. Among others, mitogen-activated protein kinases (MAPKs) have been highly implicated in the development of PD, and regulating components of their activity are indicated as promising therapeutic targets. Methods: To further define how MAPKs expression is related to the glial response and neuronal cell death, Parkinsonism was induced under an acute regimen in old mice. Moreover, the sacrifice was carried out at different time points (4, 8, 24, and 48 h) after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) injections to describe the early dynamic changes over time produced by the intoxication. Results: The results revealed that neuronal death increases as glial response increases in the nigrostriatal pathway. It was observed that both processes increase from 4 h in the ventral mesencephalon (VM), and neuronal death becomes significant at 48 h. In the striatum, they were significantly increased from 48 h after the MPTP administration compared with that in the control mice. Moreover, the p-ERK levels decrease, while phospho-p38 expression increases specifically in the striatum at 48 h after MPTP intoxication. Conclusions: The importance of these data lies in the possibility of elucidating the underlying mechanisms of neurodegenerative processes under aging conditions to provide knowledge for the search of solutions that slow down the progression of PD.
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dc.identifier.citationGil-Martinez AL, Cuenca-Bermejo L, Gallo-Soljancic P, Sanchez-Rodrigo C, Izura V, Steinbusch HWM, Fernandez-Villalba E, Herrero MT. Study of the Link Between Neuronal Death, Glial Response, and MAPK Pathway in Old Parkinsonian Mice. Front Aging Neurosci. 2020 Jul 29;12:214. doi: 10.3389/fnagi.2020.00214. PMID: 32848701; PMCID: PMC7403503.
dc.identifier.doihttps://doi.org/10.3389/fnagi.2020.00214
dc.identifier.eissn1663-4365
dc.identifier.urihttp://hdl.handle.net/10201/184969
dc.languageeng
dc.publisherFrontiers Media
dc.relationthe Spanish Ministry of Science and Innovation (FIS PI13 01293), Fundación Séneca (19540/PI/14), and Nutrafur S.A. “Smartfoods and Cognition” (2015-2018, IDI20141212) to MH.
dc.relation.publisherversionhttps://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2020.00214/full
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectParkinsonism
dc.subjectAging
dc.subjectNeurodegeneration
dc.subjectNeuroinflammation
dc.subjectMAPKs
dc.subject.odsObjetivo 3: Salud
dc.titleStudy of the link between neuronal death, glial response, and MAPK pathway in old parkinsonian mice
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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