Publication: Overexpression of Aquaporin-1 in lung
adenocarcinomas and pleural mesotheliomas
Authors
López-Campos, José Luis ; Sánchez Silva, Rocío ; Gómez Izquierdo, Lourdes ; Márquez, Eduardo ; Ortega Ruiz, Francisco ; Cejudo, Pilar ; Barrot Cortés, Emilia ; Toledo Aral, Juan José ; Echevarría, Miriam
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Aquaporin-1 (AQP1) is the main water
channel responsible for water transport through many
epithelia and endothelia. The latest evidence pointed
toward an important role of this protein also in gas
permeation, angiogenesis, cell proliferation and
migration. In the present work we studied the expression
of AQP1 by immunohistochemical staining of 92 lung
biopsies from patients diagnosed with a pleuropulmonary
tumor (71 lung and 21 pleural neoplasms).
AQP1 expression was analyzed comparing the results
among the different histological patterns and against 9
control cases (5 parenchyma and 4 healthy pleura). Clear
staining of AQP1 was detected in 39 of the 92 tumors
analyzed. In parenchyma, AQP1 was more frequently
detected in primary lung adenocarcinomas (55%,
P<0.001); in contrast, small cell carcinomas were the
least AQP1 expressive tumors studied (93% of negative
staining, P<0.05). Carcinomas analyzed in pleura
(mesotheliomas and metastatic adenocarcinomas) also
revealed strong expression of AQP1. High expression of
this protein was detected in small capillaries in areas
near or surrounding the tumor, and novel intense AQP1
immunostaining was detected over thicker alveolar walls
in alveoli inside or next to the tumoral tissue regardless
of the tumor type. An important role of AQP1 in tumor
angiogenesis is sustained by the abundant expression of
this protein in the endothelia of tumor capillaries.
Further studies are necessary to elucidate the potential
pathophysiological role of this protein in pleuropulmonary
neoplasms.
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