Melatonin and cancer: a polyhedral network where the source matters

Tomas-Loba, Antonia; Bonmatí Carrión, María de los Ángeles

Publication:
Melatonin and cancer: a polyhedral network where the source matters

dc.contributor.author	Tomas-Loba, Antonia
dc.contributor.author	Bonmatí Carrión, María de los Ángeles
dc.contributor.department	Anatomía Humana y Psicobiología
dc.date.accessioned	2025-02-01T23:17:27Z
dc.date.available	2025-02-01T23:17:27Z
dc.date.issued	2021-02-01
dc.description	© 2021 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript, version of a Published Work that appeared in final form in Antioxidants. To access the final edited and published work see https://doi.org/10.3390/antiox10020210
dc.description.abstract	Melatonin is one of the most phylogenetically conserved signals in biology. Although its original function was probably related to its antioxidant capacity, this indoleamine has been “adopted” by multicellular organisms as the “darkness signal” when secreted in a circadian manner and is acutely suppressed by light at night by the pineal gland. However, melatonin is also produced by other tissues, which constitute its extrapineal sources. Apart from its undisputed chronobiotic function, melatonin exerts antioxidant, immunomodulatory, pro-apoptotic, antiproliferative, and anti-angiogenic effects, with all these properties making it a powerful antitumor agent. Indeed, this activity has been demonstrated to be mediated by interfering with various cancer hallmarks, and different epidemiological studies have also linked light at night (melatonin suppression) with a higher incidence of different types of cancer. In 2007, the World Health Organization classified night shift work as a probable carcinogen due to circadian disruption, where melatonin plays a central role. Our aim is to review, from a global perspective, the role of melatonin both from pineal and extrapineal origin, as well as their possible interplay, as an intrinsic factor in the incidence, development, and progression of cancer. Particular emphasis will be placed not only on those mechanisms related to melatonin’s antioxidant nature but also on the recently described novel roles of melatonin in microbiota and epigenetic regulation.
dc.format	application/pdf	es
dc.identifier.citation	Antioxidants, 2021, Vol. 10, Issue 2 : 210
dc.identifier.doi	https://doi.org/10.3390/antiox10020210
dc.identifier.issn	Electronic: 2076-3921
dc.identifier.uri	http://hdl.handle.net/10201/149962
dc.language	eng	es
dc.publisher	MDPI
dc.relation	This review was funded by Fundación Séneca, 20401/SF/17 and 19899/GERM/15; Ministerio de Ciencia, Innovación y Universidades (RYC2018-025622-I; RTI2018-093528-B-I00); Fundación FERO (BFERO2020.01) and Fundación BBVA (Leonardo Fellowship); Ministerio de Economía y Competitividad, Instituto de Salud Carlos III through a CIBERFES grant (CB16/10/00239); Diabfrail LatAm (European Union’s Horizon 2020 research and innovation programme N. 825546).	es
dc.relation.publisherversion	https://www.mdpi.com/2076-3921/10/2/210
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Melatonin
dc.subject	Cancer
dc.subject	Antitumor
dc.subject	Antioxidant
dc.subject	Circadian
dc.subject	Chronobiotic
dc.subject	Pineal
dc.subject	Extrapineal
dc.subject	Immunomodulatory
dc.subject	Light at night
dc.title	Melatonin and cancer: a polyhedral network where the source matters	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
relation.isAuthorOfPublication	92b5ee66-dc41-459a-8f32-5414d2e4d43d
relation.isAuthorOfPublication.latestForDiscovery	92b5ee66-dc41-459a-8f32-5414d2e4d43d