Publication: HSP 27 as possible prognostic factor in patients with oral squamous cell carcinoma
Authors
Lo Muzio, L. ; Leonardi, R. ; Mariggiò, M.A. ; Mignogna, M.D. ; Rubini, C. ; Vinella, A. ; Pannone, G. ; Giannetti, L. ; Serpico, R. ; Testa, N.F. ; De Rosa, G. ; Staibano, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
HSP27 belongs to the Heat shock protein
(HSP) family, which plays essential functions in cells
under physiological conditions and prevents stressinduced
cellular damage. The aim of this study was to
investigate the biological role of HSP27 in oral
tumorigenesis. Materials and methods: Seventy-nine
cases of oral squamous cell carcinoma and 10 cases of
normal mucosa were analysed for HSP27 expression by
immunohistochemistry. Moreover, the western blot
analysis was performed on two cases of normal mucosa
and five cases of OSCC. Results: Normal oral mucosa
showed a suprabasal expression of HSP27. Twenty-four
cases of SCC (30.7%) showed a diffuse staining for
HSP27, and 48 cases (60.3%) showed instead a decrease
in staining, which was diffuse, homogeneous, or with
alternation of positive and negative areas in a single
tumor (“mosaic” pattern). Only 7 cases of OSCC (7.5%)
were completely negative for HSP27. Frequency of
lymph node metastases was higher in HSP27-negative
tumours (3/7, 42.8%) than in HSP-reduced (16/48,
33.3%) or positive ones (5/26, 19.2%). Regard staging,
stages I and II had a higher score than stages III and IV
(stage I > stage II > stage III > stage IV). There was also
a statistically significant correlation between HSP27
expression and grade: HSP27 expression was reduced in poorly differentiated tumours (P < 0.05). When analysed
for prognostic significance, patients with
negative/reduced HSP27 expression had poorer survival
rates than the group with positive HSP27 expression (P
< 0.05). The statistical analysis of these findings showed
no significant correlation between HSP27 expression,
sex, and tumour size. Conclusion: Cases with reduced
expression were more aggressive and poorly
differentiated. These data suggest that HSP27 expression may be useful in order to identify cases of oral squamous
cell carcinoma with more aggressive and invasive
phenotype providing novel diagnostic and prognostic
information on individual patient survival with oral
cancers.
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