Publication: Human axillary apocrine glands: proteins
involved in the apocrine secretory mechanism
Authors
Stoeckelhuber, Mechthild ; Schubert, Christoph ; Kesting, Marco R. ; Loeffelbein, Denys J. ; Nieberler, Markus ; Koehler, Claudia ; Welsch, Ulrich
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The apocrine secretory mechanism is a mode
of secretion by which the apical part of the cell
cytoplasm is pinched off, which leads to the formation of
an aposome. The distinct mechanism of formation and
decapitation of the aposome is not well investigated.
Only few proteins are known that are involved in this
secretory mechanism. We studied the human axillary
apocrine gland and looked at proteins associated with
cytokinesis, a process that is comparable to the pinchingoff
mechanism of apocrine glandular cells. By
immunohistochemistry, we detected actin, myosin II,
cytokeratin 7 and 19, α- and ß-tubulin, anillin, cofilin,
syntaxin 2, vamp8/endobrevin and septin 2. In highly
active glandular cells, these proteins are located at the
base of the apical protrusion when the aposome is in the
process of being released or are concentrated in the cap
of the apical protrusion. These findings demonstrate new
insights on apocrine secretory mechanisms and point to
similarites to the terminal step of cytokinesis, which is
regulated by a SNARE-mediated membrane fusion
event.
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