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Sargassum horneri extract containing polyphenol alleviates DNCB-induced atopic dermatitis in NC/Nga mice through restoring skin barrier function

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dc.contributor.authorMihindukulasooriya, Suyama Prasansali
dc.contributor.authorDinh, Duong Thi Thuy
dc.contributor.authorHerath, Kalahe Hewage Iresha Nadeeka Madushani
dc.contributor.authorKim, Hyo Jin
dc.contributor.authorHan, Eui Jeong
dc.contributor.authorCho, Jinhee
dc.contributor.authorKo, Mi Ok
dc.contributor.authorJeon, You Jin
dc.contributor.authorAhn, Ginnae
dc.contributor.authorJee, Youngheun
dc.date.accessioned2023-03-01T09:02:49Z
dc.date.available2023-03-01T09:02:49Z
dc.date.issued2022
dc.description.abstractAtopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunction. Sargassum horneri (S. horneri) is a brown alga that has been widely used in traditional medicine of eastern Asian countries. Recent studies proved that a brown alga S. horneri has anti-inflammatory activity. In this study, we investigated the effect of S. horneri ethanol extract (SHE) against AD in 2,4-dinitrobenzene (DNCB) induced AD in NC/Nga mice. We observed that SHE treatment decreased the epidermal thickness and epidermal hyperplasia that had been worsened through DNCB application. Moreover, SHE significantly inhibited the proliferation of mast cells and decreased the expression of IL-13 on CD4+ cells prompted by elevated thymic stromal lymphopoietin (TSLP) expression in DNCB-induced AD in mice. We also demonstrated that SHE directly inhibited the expression of keratinocyte-produced TSLP known to exacerbate skin barrier impairment. Especially, the decrease of filaggrin, an integral component of proper skin barrier function through a function in aggregating keratin filaments, observed in DNCB-induced AD mice was significantly improved when treated with SHE. More importantly, we proved that SHE was able to decrease the serum levels of IgG1 and IgG2a, two crucial factors of AD, indicating the protective effect of SHE. Taken together, our findings suggest that SHE may protect NC/Nga mice against DNCB-induced AD via promoting skin barrier function.es
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dc.format.extent14es
dc.identifier.citationHistology and Histopathology Vol. 37, nº9 (2022)
dc.identifier.doihttps://doi.org/10.14670/HH-18-473
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/128906
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBrown algaes
dc.subjectThymic stromal lymphopoietin (TSLP)es
dc.subjectFilaggrines
dc.subjectSkin barrieres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleSargassum horneri extract containing polyphenol alleviates DNCB-induced atopic dermatitis in NC/Nga mice through restoring skin barrier functiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.37, nº9 (2022)