Molecular identity of the lateral lemniscus nuclei in the adult mouse brain

García-Guillén, Isabel M.; Aroca Tejedor,  Pilar; Marín San Leandro, Faustino

Publication:
Molecular identity of the lateral lemniscus nuclei in the adult mouse brain

dc.contributor.author	García-Guillén, Isabel M.
dc.contributor.author	Aroca Tejedor, Pilar
dc.contributor.author	Marín San Leandro, Faustino
dc.contributor.department	Anatomía Humana y Psicobiología
dc.date.accessioned	2023-11-15T10:53:59Z
dc.date.available	2023-11-15T10:53:59Z
dc.date.issued	2023-03-09
dc.description	© 2023 García-Guillén, Aroca and Marín. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) http://creativecommons.org/licenses/by- /4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. This document is the Published version of a Published Work that appeared in final form in Frontiers in Neuroanatomy. To access the final edited and published work see https://doi.org/10.3389/fnana.2023.1098352	es
dc.description.abstract	The dorsal (DLL), intermediate (ILL), and ventral (VLL) lateral lemniscus nuclei are relay centers in the central auditory pathway of the brainstem, commonly referred to as the lateral lemniscus nuclei (LLN). The LLN are situated in the prepontine and pontine hindbrain, from rhombomeres 1 to 4, extending from the more rostral DLL to the caudal VLL, with the ILL lying in between. These nuclei can be distinguished morphologically and by topological and connectivity criteria, and here, we set out to further characterize the molecular nature of each LLN. We searched in situ hybridization studies in the Allen Mouse Brain Atlas for genes differentially expressed along the rostrocaudal axis of the brainstem, identifying 36 genes from diverse functional families expressed in the LLN. Available information in the databases indicated that 7 of these 36 genes are either associated with or potentially related to hearing disorders. In conclusion, the LLN are characterized by specific molecular profiles that reflect their rostrocaudal organization into the three constituent nuclei. This molecular regionalization may be involved in the etiology of some hearing disorders, in accordance with previous functional studies of these genes.	es
dc.format	application/pdf	es
dc.format.extent	14	es
dc.identifier.citation	Front. Neuroanat., 2023 Volume 17 - 1098352
dc.identifier.doi	10.3389/fnana.2023.1098352
dc.identifier.issn	Electrónico: 1662-5129
dc.identifier.uri	http://hdl.handle.net/10201/135730
dc.language	eng	es
dc.publisher	Frontiers Media	es
dc.relation	Sin financiación externa a la Universidad	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Aauditory pathway	es
dc.subject	Hearing pathway	es
dc.subject	Cochlear nuclei	es
dc.subject	Superior olive	es
dc.subject	Iinferior colliculus,	es
dc.subject	Gene expression	es
dc.title	Molecular identity of the lateral lemniscus nuclei in the adult mouse brain	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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