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Histopathological changes of the hippocampus neurons in brain injury

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dc.contributor.authorDong Ri Lies
dc.contributor.authorTakaki Ishikawaes
dc.contributor.authorDong Zhao
dc.contributor.authorTomomi Michiue
dc.contributor.authorLi Quan
dc.contributor.authorBao Li Zhu
dc.contributor.authorHitoshi Maeda
dc.date.accessioned2013-09-24T11:45:42Z
dc.date.available2013-09-24T11:45:42Z
dc.date.issued2009
dc.description.abstractThe glial fibrillary acidic protein (GFAP) is known as a peculiar marker of mature astrocytes of the central nervous system (CNS). However, we found distinct immunopositivity to a monoclonal anti-GFAP reagent in the hippocampus neurons in head injury fatalities. The present study investigated the neuronal and neuroglial GFAP-immunopositivity in the hippocampus in a series of head injury cases, which included acute and subacute/delayed deaths (n=17 and n=73, respectively), and acute cardiac death (n=13), delayed death due to multiple organ failure from nonhead injury (n=6), and pneumonia (n=9) cases were examined as controls. GFAP-immunopositivity in the neurons was frequently observed in CA4, CA3 and CA2 regions in cases of subacute/delayed head injury death that showed marked brain swelling accompanied by secondary brain stem hemorrhages, showing an inverse relationship to that in astrocytes. These findings suggest possible induction of GFAP or a related protein in hippocampus neurons depending on the severity of brain swelling following head injury.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/36068
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectImmunohistochemistryes
dc.subjectHippocampuses
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleHistopathological changes of the hippocampus neurons in brain injuryes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24, nº9 (2009)