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Guishen-erxian decoction can improve ovarian function in rats with premature ovarian failure by inhibiting oxidative stress and granulosa cell DNA fragmentation mediated by the PI3K/Akt/FOXO3a pathway

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dc.contributor.authorYuhua He
dc.contributor.authorWenhui Wang
dc.contributor.authorYingyun Liu
dc.contributor.authorDanna Chen
dc.contributor.authorYongqi Shen
dc.contributor.authorChengjie Liang
dc.contributor.authorHuanmei Zhong
dc.contributor.departmentBiología Celular e Histología
dc.contributor.editorUniversidad de Murcia, Departamento de Biología Celular e Histología
dc.date.accessioned2026-03-25T17:10:51Z
dc.date.available2026-03-25T17:10:51Z
dc.date.issued2026
dc.description.abstractBackground. The aim of this study was to establish a rat model of premature ovarian failure (POF) with cyclophosphamide (CTX), and explore the molecular basis of POF and the mechanism of Guishen Erxian Decoction (GSEXD) to improve POF from the perspective of oxidative stress regulation of ovarian granulosa cell (OGC) DNA fragmentation. Method. The study utilized SD rats to establish a POF model via CTX. Rats were divided into Control, POF group, three GSEXD dosage groups (low, medium, high), and a GSEXD+PI3K agonist group to assess GSEXD’s therapeutic effects on oxidative stress, DNA fragmentation and ovarian damage. Result. GSEXD can improve the body weight, ovarian index, pathological status, and hormone secretion of POF rats, and inhibit ovarian oxidative stress and DNA fragmentation. In addition, GSEXD inhibits the activation of the PI3K/Akt/FoxO3a pathway. PI3K agonist 740 Y-P can reverse the effects of GSEXD on ovarian function, ovarian antioxidant capacity, and granulosa cell DNA fragmentation in POF rats. Conclusion. Inhibition of oxidative stress damage and excessive DNA fragmentation of granulosa cells is a key pathway for GSEXD to promote follicle growth and development and alleviate ovarian function decline, which may be related to the inhibition of the PI3K/AKT/FOXO3a pathway by GSEXD.
dc.formatapplication/pdf
dc.format.extent13
dc.identifier.doihttps://doi.org/10.14670/HH-18-984
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/223141
dc.languageeng
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectOxidative stress damage
dc.subjectCyclophosphamide-induced ovarian failure
dc.subjectPI3K/Akt activation
dc.subjectTraditional Chinese medicine formula
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleGuishen-erxian decoction can improve ovarian function in rats with premature ovarian failure by inhibiting oxidative stress and granulosa cell DNA fragmentation mediated by the PI3K/Akt/FOXO3a pathway
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology, Vol.41, Nº4, (2026)