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Unraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabetes

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dc.contributor.authorIborra Egea, Oriol
dc.contributor.authorSantiago Vacas, Evelyn
dc.contributor.authorYurista, Salva
dc.contributor.authorLupon, Josep
dc.contributor.authorPacker, Milton
dc.contributor.authorHeymans, Stephane
dc.contributor.authorPascual Figal, Domingo A.
dc.contributor.authorLax PĂ©rez, Antonio Manuel
dc.contributor.authorBayes Genis, Antoni
dc.contributor.departmentMedicina
dc.date.accessioned2024-01-23T12:31:46Z
dc.date.available2024-01-23T12:31:46Z
dc.date.issued2019-10
dc.description.abstracthe mechanism of action of empagliflozin in heart failure with reduced ejection fraction (HFrEF) was deciphered using deep learning in silico analyses together with in vivo validation. The most robust mechanism of action involved the sodium-hydrogen exchanger (NHE)-1 co-transporter with 94.7% accuracy, which was similar for diabetics and nondiabetics. Notably, direct NHE1 blockade by empagliflozin ameliorated cardiomyocyte cell death by restoring expression of X-linked inhibitor of apoptosis (XIAP) and baculoviral IAP repeat-containing protein 5 (BIRC5). These results were independent of diabetes mellitus comorbidity, suggesting that empagliflozin may emerge as a new treatment in HFrEF.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationJACC Basic Transl Sci. 2019 Oct 23 4(7):831-840.doi: 10.1016/j.jacbts.2019.07.010.
dc.identifier.doi10.1016/j.jacbts.2019.07.010
dc.identifier.urihttp://hdl.handle.net/10201/137594
dc.languageenges
dc.relationDr. Yurista is supported by Indonesia Endowment Fund for Education grant LPDP 20150722083422.es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleUnraveling the Molecular Mechanism of Action of Empagliflozin in Heart Failure With Reduced Ejection Fraction With or Without Diabeteses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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