Publication: Rab GTPases-cargo direct interactions: fine modulators of intracellular trafficking
Authors
Aloisi, Ana Laura ; Bucci, Cecilia
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Rab proteins are a large family of monomeric
GTPases that comprise about 70 members. These
proteins cycle from a GDP-bound to a GTP-bound state
and are considered molecular switches of membrane
traffic. Indeed, they control several steps of vesicular
trafficking such as vesicle formation, vesicle movement
on actin and tubulin cytoskeletal tracks, vesicle
tethering, docking and fusion to the target compartment.
Accordingly, Rab proteins are considered key factors in
vesicular trafficking as they have a fundamental role in
specifying identity and routing of vesicles and
organelles. Given their role in membrane traffic, it is not
surprising that Rab proteins control the cellular fate of
several membrane molecules such as signal transduction
receptors and ion channels, being thus fundamental for
their correct function. However, much evidence of
interaction of a number of Rab proteins with cargo has
been reported, raising the question of the functional
meaning of these interactions. Indeed, Rab proteins have
been demonstrated to directly interact with several
membrane proteins, such as signaling receptors,
immunoglobulin receptors, integrins and ion channels.
Growing evidence indicates that, through interactions
with Rab proteins, cargos directly control their own fate.
Furthermore, often a cargo protein has the ability to
interact with more than one Rab and/or with the same
Rab in different activation states. This review focuses on
these interactions highlighting their role in modulating
cargo’s trafficking and functions.
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Citation
Histology and Histopathology, vol. 28, nº 7 (2013)
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