Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma

Morales, Eva; Duffy, David

Publication:
Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma

dc.contributor.author	Morales, Eva
dc.contributor.author	Duffy, David
dc.contributor.department	Ciencias Sociosanitarias
dc.date.accessioned	2024-01-31T08:23:59Z
dc.date.available	2024-01-31T08:23:59Z
dc.date.issued	2019
dc.description	©<2019>. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Published, version of a Published Work that appeared in final form in Frontiers in pediatrics. To access the final edited and published work see https://doi.org/10.3389/fped.2019.00499
dc.description.abstract	Asthma is a heterogeneous disease that results from the complex interaction between genetic factors and environmental exposures that occur at critical periods throughout life. It seems plausible to regard childhood-onset and adult-onset asthma as different entities, each with a different pathophysiology, trajectory, and outcome. This review provides an overview about the role of genetics and gene-environment interactions in these two conditions. Looking at the genetic overlap between childhood and adult onset disease gives one window into whether there is a correlation, as well as to mechanism. A second window is offered by the genetics of the relationship between each type of asthma and other phenotypes e.g., obesity, chronic obstructive pulmonary disease (COPD), atopy, vitamin D levels, and inflammatory and immune status; and third, the genetic-specific responses to the many environmental exposures that influence risk throughout life, and particularly those that occur during early-life development. These represent a large number of possible combinations of genetic and environmental factors, at least 150 known genetic loci vs. tobacco smoke, outdoor air pollutants, indoor exposures, farming environment, and microbial exposures. Considering time of asthma onset extends the two-dimensional problem of gene-environment interactions to a three-dimensional problem, since identified gene-environment interactions seldom replicate for childhood and adult asthma, which suggests that asthma susceptibility to environmental exposures may biologically differ from early life to adulthood as a result of different pathways and mechanisms of the disease.	es
dc.format	application/pdf	es
dc.identifier.citation	Frontiers in Pediatric, Sec. Pediatric Pulmonology Volume 7 - 2019
dc.identifier.doi	https://doi.org/10.3389/fped.2019.00499
dc.identifier.uri	http://hdl.handle.net/10201/138226
dc.language	eng	es
dc.relation	EM was funded by Miguel Servet Grant Fellowships (MS/00046 and CPII19/00019) awarded by the Spanish Instituto de Salud Carlos III (ISCIII), Ministry of Economy and Competitiveness and Fondos FEDER.	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.title	Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es