Publication: Sex-related expression of sialic acid acceptor sugars in the mouse submandibular gland. Simultaneous visualization by confocal laser scanning microscopy
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Date
1999
Authors
Menghi, Giovanna ; Bondi, A.M. ; Marchetti, L. ; Sabbieti, M.G. ; Gabrielli, M.G. ; Materazzi, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The novel combination of sialidase digestion
with simultaneous PNA and DBA binding yielded
marked differences on sialoglycoconjugate occurrence
and distribution in the mouse submandibular gland
acinar cells of the two sexes. Striking differences in the
structure of terminal disaccharides within stored
secretory sialoglycoconjugates were also found. High
content of sialic acid, characterized by the terminal
sequence sialic acid-a-N-acetylgalactosamine, was
established to only occur in the male acini where
secretory cells appeared to be differently stained; indeed,
some cells exhibited codistribution of sialic acid-a-Nacetylgalactosamine
and sialic acid-B-galactose terminal
disaccharides, whereas other ones exclusively contained
one of the two kinds of terminal sequences. In the
female acinar cells, the secretory products were found to
be almost exclusively composed by glycoconjugates
having sialic acid subtended to B-galactose without
appreciable differences between acinar cells. Our finding
of such extensive differences in the acinar cells of male
and female mice adds new insights into the submandibular
gland sexual dimorphism, commonly
attributed to the androgen responsiveness of the granular
convoluted tubule portion of the gland.
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