Publication: Effect of irradiation on autogenous bone transplantation in rat parietal bone
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Date
2000
Authors
Takekawa, M. ; Matsuda, Mikio ; Ohotubo, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
To determine the appropriate time for bone
reconstruction after irradiation, the healing process after
autogenous iliac bone transplantation in the irradiated
parietal bone was examined by scanning electron
microscopy and light microscopy. Bone transplantation
was carried out at the second and the fourth weeks after
Cobalt-sixty ( 6 0 ~ o i)r radiation with calculated dose and
fractionation. Animals without irradiation were used as
control.
The results show the appearance of mesenchymal
cells and blood vessels around the transplantation to be
extremely few one week after transplantation which was
carried out at the second week after irradiation. These
inhibitions were still seen two weeks after transplantation.
Four weeks after transplantation, there were
no differences in the bone formation among the
experimental groups. Bone formation in the transplantation
at the fourth week after irradiation was similar
to that of the control group. Microvascularization in the
transplantation at the second week after irradiation was
inhibited one week after transplantation.
The delay in bone healing was responsible for the
retardation of revascularization and caused microcirculatory
failures as well as the damage of osteogenic
cells. It is quite clear that damaged cells and tissues
recovered by the elapse of time under the irradiation procedure employed in this study and also that bone
formation was carried out in the physiological process.
We think that bone transplantation after irradiation
should be done after recovery from the radiation damage
to the periosteal cells and the blood vessels.
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