Publication: Cell proliferation in the developing rat pineal gland.A bromodeoxyuridine immunohistochemical study
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Date
2000
Authors
Calvo, J.L. ; Boya, J. ; Carbonell, A.L. ; García-Mauriño, J.E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The immunohistochemical detection of
bromodeoxyuridine (BrdU) was used to study the cell
proliferation in the developing rat pineal gland, from the
appearance of pineal primordium in the embryonic day
15 (E15) until 30 days after birth. The results showed
three different proliferative phases. From E15 to E21,
the pineal gland shows a phase of rapid proliferation.
The second phase corresponds to the first postnatal
week, in which the number of labeled cells per surface
unit decreases suddenly to values between 20% to 10%
of those of embryonic period. From the second postnatal
week onwards, the number of BrdU-positive cells
progressively decreases.
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