Publication: Review of renal oncocytoma with focus on clinical and pathobiological aspects
Authors
Kuroda, Naoto ; Toi, M. ; Hiroi, Makoto ; Shuin, T. ; Enzan, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Renal oncocytomas account for about 3-7%
of all renal tumors. Macroscopically, the cut surface of
the tumor is generally mahogany brown or dark red in
color. A central scar is occasionally observed.
Histologically, tumor cells with finely granular
cytoplasm proliferate in an edematous, myxomatous or
hyalinized stroma with a nested, tubulocystic, solid or
trabecular pattern. Ultrastructurally, tumor cells contain
many mitochondria with lamellar cristae. Mitochondrial
DNA alterations are consistently observed in renal
oncocytomas. In chromosomal analysis, renal
oncocytomas comprise a heterogenous group. Combined
loss of chromosomes Y and 1, rearrangements affecting
band 11q12-13, involvement of 12q12-13, loss of 14q,
and the lack of combination of LOH at specific
chromosomal sites have been reported. In differential
diagnosis, the histological separation from chromophobe
RCCs is of great importance. In such a setting,
ultrastructural or chromosomal analysis is very useful.
However, there are several findings suggesting a close
relationship between chromophobe RCC and oncocytoma. First, both tumors share a phenotype of
intercalated cells of the collecting duct system and
mitochondrial DNA alterations. Second, some cases of
coexistent oncocytoma and chromophobe RCC,
designated as "renal oncocytosis", have recently been
reported. Third, oncocytic variants of chromophobe
RCCs that have similar ultrastructural features to those
of oncocytomas have been reported. Fourth, the
existence of chromophobe adenoma, which is the benign
counterpart of chromophobe RCC and shows loss of
chromosomes Y and 1, has recently been suggested.
Finally, although almost all oncocytomas behave in a
benign fashion, some cases of oncocytoma that caused
metastasis or resulted in death have also been reported.
Therefore, further studies are needed to resolve these
problems and also to elucidate the genetic mechanisms responsible for the occurrence of oncocytomas.
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