Publication: Natural IgM antibodies, the ignored weapons in tumour immunity
Authors
Brändlein, S. ; Vollmers, H.P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
During its lifetime each multi-cellular
organism is permanently exposed to infectious agents
and transformed cells. Without an early recognition and
a rapid elimination system, there would be no
development and no life. The innate or natural immunity,
seems to be more important for the detection of
“foreign” cells and particles than has been thought. Even
if not every transformed cell has the ability and potency
for malignant behaviour, the important question is not,
why malignant cells arise, but instead, why malignancy
occurs so infrequently. We have shown in a recent paper,
by using the human hybridoma technology, that tumour
immunity is not induced by malignant cells, but instead
the result of innate immunity and that natural IgM
antibodies play an important role in immunosurveillance
mechanisms against transformed cells in humans
(Brändlein et al., 2003b). In this review typical features
of natural IgM antibodies are discussed and tumourspecific
reactivities and different apoptotic functions on
epithelial cancer cells are illustrated.
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Citation
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