Publication: Synthesis and Characterization of New Ruthenium (II) Complexes of Stoichiometry [Ru(p-Cymene)Cl2L] and Their Cytotoxicity against HeLa-Type Cancer Cells
Authors
Fuster, M. G. ; Moulefera, I. ; Montalbán, M. G. ; Pérez, J. ; Víllora Cano, Gloria ; García, G.
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Facultad de Química
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Publisher
MDPI
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DOI
https://doi.org/10.3390/molecules27217264
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info:eu-repo/semantics/article
Description
© 2022 by the authors____ This document is the published version of a published work that appeared in final form in Molecules____
This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0 ____
To access the final edited and published work see:
https://doi.org/10.3390/molecules27217264
Abstract
When the [Ru(p-cymene)( -Cl)Cl]2 complex is made to react, in dichloromethane, with the
following ligands: 2-aminobenzonitrile (2abn), 4-aminobenzonitrile (4abn), 2-aminopyridine (2ampy)
and 4-aminopyridine (4ampy), after addition of hexane, the following compounds are obtained:
[Ru(p-cymene)Cl2(2abn)] (I), [Ru(p-cymene)Cl2(4abn)] (II), [Ru(p-cymene)Cl2(2ampy] (III) and [Ru(pcymene)
Cl2( -(4ampy)] (IV). All the compounds are characterized by elemental analysis of carbon,
hydrogen and nitrogen, proton nuclear magnetic resonance, COSY 1H-1H, high-resolution mass
spectrometry (ESI), thermogravimetry and single-crystal X-ray diffraction (the crystal structure of III
is reported and compared with the closely related literature of II). The cytotoxicity effects of complexes
were described for cervical cancer HeLa cells via 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium
bromide (MTT) assay. The results demonstrate a low in vitro anticancer potential of the complexes.
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Citation
Molecules 2022, 27(21), 7264
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