Publication: Experimental neurocytomas
Authors
Vaquero, J. ; Coca, S. ; Zurita, M. ; Oya, S. ; Arias, A. ; Morales, C. ; Buján, J. ; García, N .
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Four ethyl-nitrosourea (ENU)-induced
oligodendroglioma-like tumors of the rat showing large
rosettes on haematoxylin-eosin stain were studied by
means of immunohistochemistry and electron
microscopy, and their features compared with six human
intraventricular neurocytomas. The similarities between
the experimental and human tumors studied support the
hypothesis that most of the so-called ENU-induced
oligodendrogliomas in the rat are primitive
neuroectodermal tumors with the tendency to
differentiate toward a neuronal phenotype, and also
suggest that the ENU-model of neurocarcinogenesis is
useful for the induction of experimental neurocytomas.
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Citation
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