Publication: The study of clinicopathologic features of cervical squamous carcinoma with invasive micropapillary like pattern and phenotype
Authors
Wang, Hongyu ; Yang, Kun ; Li, Qiuyao ; Su, Wenjing ; Liu, Xiaoqian ; Feng, Kun ; Song, Haiyun ; Li, Shuen ; Jiang, Huifeng
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/ 10.14670/HH-18-464
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info:eu-repo/semantics/article
Description
Abstract
Invasive micropapillary carcinoma has
been reported in the adenocarcinoma of many organs
including cervix, and many studies have proved it has
more invasive biological behavior. This study, for the
first time, reports cervical squamous carcinoma with
invasive micropapillary like pattern and phenotype
(IMLPP) and further investigates its clinicopathologic
features. Cervical squamous carcinoma with IMLPP
was selected by histological characteristics and
immunohistochemical staining. All patients’ clinical
information and pathological parameters were
collected. Based on histological characteristics and
immunohistochemical staining results, 24 cases, out of
104 cases of cervical squamous carcinoma, were
identified as having invasive micropapillary like
pattern. The staining of all 24 cases with EMA and
MUC-1 showed the feature of “reverse polarity like”.
Meanwhile, patient age at diagnosis (P=0.011),
maximum invasion depth (P=0.001), maximum
diameter (P=0.015), lymphvascular space invasion
(P<0.001), pelvic lymph node metastasis (P<0.001),
metastasis (P=0.020), death (P=0.025) and FIGO
stages (P=0.001) were related to the existence of
IMLPP, independently of the proportion of IMLPP to
the whole tumor in size. Univariate and multivariate
disease-free survival analyses (follow-up time >12
months) showed significant statistical difference
between cervical squamous carcinoma with or without
IMLPP (P=0.016, P=0.043). Results from our study
suggested that IMLPP may be associated with
aggressive biological behavior in cervical squamous
carcinoma. Therefore, pathologists should pay
attention to the existence of it, no matter its proportion
with relation to the whole tumor, and bring it to the
attention of clinicians.
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Citation
Histology and Histopathology Vol. 37, nº9 (2022)
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