Comparative Study of Inhaled Fluticasone Versus Oral Prednisone in 30 Dogs with Cough and Tracheal Collapse

Talavera López, Jesús; Sáez Mengual, Oscar; Fernández del Palacio, María Josefa

Publication:
Comparative Study of Inhaled Fluticasone Versus Oral Prednisone in 30 Dogs with Cough and Tracheal Collapse

dc.contributor.author	Talavera López, Jesús
dc.contributor.author	Sáez Mengual, Oscar
dc.contributor.author	Fernández del Palacio, María Josefa
dc.contributor.department	Medicina y Cirugía Animal
dc.coverage.spatial	España	es
dc.coverage.temporal	2023	es
dc.date.accessioned	2024-01-24T16:55:03Z
dc.date.available	2024-01-24T16:55:03Z
dc.date.issued	2023-09-01
dc.description	©2023. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published, version of a Published Work that appeared in final form in Veterinary Sciences. To access the final edited and published work see https://doi.org/10.3390/vetsci10090548	es
dc.description.abstract	Coughing is common in dogs with tracheal collapse (TC). The use of inhaled corticosteroids is less widespread than oral ones. This study aims to compare the effects of oral and inhaled corticosteroids in dogs with cough and TC. Thirty dogs were prospectively included and randomized to the prednisone oral group (OG, 14) or fluticasone inhaled group (IG, 16). A clinical score (CS) based on four clinical parameters (respiratory distress, cough episodes, cough frequency, tracheal sensitivity) was monitored at the hospital (enrolment and weeks 2 and 4). Water intake, urination habits, and adherence and tolerance to treatments were monitored weekly. Significant improvements in clinical parameters were identified in both groups throughout the study. Between-group (OG–IG) comparisons revealed no significant differences, indicating equivalent improvement. At the study’s endpoint, the IG dogs had a significantly lower CS (5.69 ± 0.79) than OG dogs (6.43 ± 1.02, p < 0.05). Adherence and tolerance were comparable. From weeks 2 to 4, OG dogs were significantly thirstier and urinated more frequently than IG dogs. In conclusion, fluticasone provided good tolerability and efficacy in controlling cough in dogs with TC, and they showed a lower incidence of signs of hypercortisolism compared to prednisone. These data encourage the use of inhaled fluticasone in dogs with cough and TC.	es
dc.format	application/pdf	es
dc.format.extent	13	es
dc.identifier.citation	Veterinary Sciences. 2023, 10, 548
dc.identifier.doi	https://doi.org/10.3390/vetsci10090548
dc.identifier.uri	http://hdl.handle.net/10201/137691
dc.language	eng	es
dc.relation	Sin financiación externa a la Universidad	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Veterinaria	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología	es
dc.subject.other	CDU::6 - Ciencias aplicadas::63 - Agricultura. Silvicultura. Zootecnia. Caza. Pesca::636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticos	es
dc.title	Comparative Study of Inhaled Fluticasone Versus Oral Prednisone in 30 Dogs with Cough and Tracheal Collapse	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es