Publication: Time of origin of the rat pineal gland cells. A bromodeoxyuridine immunohistochemical study
Authors
Calvo, J.L. ; Boya, J. ; Carbonell, A.L. ; García-Mauriño, J.E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The immunohistochemical detection of
bromodeoxyuridine (BrdU) was used to study the time
of origin of the cells in the pineal gland of the rat. A
study was made involving 17 groups of 4 rats each,
administered with a single dose of bromodeoxyuridine
(BrdU, 25 mg/kg) in 7 phases of the embryonic period
(E15 to E21) and in 10 postnatal phases (between P0 and
P30), followed by determination in each rat of the
number of visible immune-labeled cells in the pineal
gland 60 days after birth. The results show that
approximately 60% of the pineal cells underwent the last
division(s) prior to differentiation in the prenatal period
between E18 and E21. The rest of the pineal cells
originated after birth, particularly in the first 5 postnatal
days.
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