Publication:
Sphingosine 1-phosphate and its regulatory role in vascular endothelial cells

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Qiu-37-213-226-2022.pdf(1.65 MB)
Date
2022
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Authors
Qiu, Yan ; Shen, Junyi ; Jiang, Wenli ; Yang, Yi ; Liu, Xiaoheng ; Zeng, Ye
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/ 10.14670/HH-18-428
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info:eu-repo/semantics/article
Description
Abstract
Sphingosine 1-phosphate (S1P) is a bioactive metabolite of sphingomyelin. S1P activates a series of signaling cascades by acting on its receptors S1PR1-3 on endothelial cells (ECs), which plays an important role in endothelial barrier maintenance, anti-inflammation, antioxidant and angiogenesis, and thus is considered as a potential therapeutic biomarker for ischemic stroke, sepsis, idiopathic pulmonary fibrosis, cancers, type 2 diabetes and cardiovascular diseases. We presently review the levels of S1P in those vascular and vascularrelated diseases. Plasma S1P levels were reduced in various inflammation-related diseases such as atherosclerosis and sepsis, but were increased in other diseases including type 2 diabetes, neurodegeneration, cerebrovascular damages such as acute ischemic stroke, Alzheimer's disease, vascular dementia, angina, heart failure, idiopathic pulmonary fibrosis, communityacquired pneumonia, and hepatocellular carcinoma. Then, we highlighted the molecular mechanism by which S1P regulated EC biology including vascular development and angiogenesis, inflammation, permeability, and production of reactive oxygen species (ROS), nitric oxide (NO) and hydrogen sulfide (H2S), which might provide new ways for exploring the pathogenesis and implementing individualized therapy strategies for those diseases
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Sphingosine 1-phosphate , Endothelial cells , Permeability , Angiogenesis , Inflammation , ROS , NO , H2S
Citation
Histology and Histopathology Vol. 37, nº3 (2022)
URI
http://hdl.handle.net/10201/128424
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Histology and histopathology Vol.37, nº3 (2022)
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