Publication: Immunohistochemical and Western blot analysis of two protein tyrosine phosphatase receptors, R and Z1, in colorectal carcinoma, colon adenoma and normal colon tissues
Authors
Woźniak, Marta ; Gamian, Elżbieta ; Łaczmańska, Izabela ; Sąsiadek, Maria M. ; Duś-Szachniewicz, Kamila ; Ziółkowski, Piotr
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Two classes of proteins, namely tyrosine
kinases (PTK) and phosphatases (PTP), play an
important role in cell proliferation and differentiation,
thus leading to an acceleration or inhibition of tumour
growth. The role of the above proteins in colorectal
carcinoma (CRC) growth is a well-known event. In this
study we carried out immunohistochemical and Western
blot analysis of colorectal carcinoma, adenoma and
normal colon tissue in relation to two protein tyrosine
phosphatase receptors, R and Z1. Twenty-five cases of
CRC were analyzed and the results were compared with
similar data obtained in non-malignant tissues. High
expression of both PTP receptors was observed in all
examined cases of CRC, adenoma and normal colon
tissue in this study. These results are not in line with
recently published data, showing that genetic coding for
PTPRR and PTPRZ1 were hypermethylated in CRC’s.
We presume that the protein tyrosine phosphatase
overexpression in colorectal carcinoma is not enough to
protect from the progression of disease.
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Citation
Histology and Histopathology, vol. 29, nº 5, (2014)
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