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A subpopulation of airway epithelial cells that express hepatocyte nuclear factor 4α - its implication in the development of non- terminal respiratory unit-type lung adenocarcinoma.

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dc.contributor.authorOkudela, Koji
dc.contributor.authorAra, Hiromasa
dc.contributor.authorKitamura, Hideya
dc.contributor.authorBaba, Tomohisa
dc.contributor.authorSuzuki, Takehisa
dc.contributor.authorMitsui, Hideaki
dc.contributor.authorSugiyama, Misaki
dc.contributor.authorHonda, Emi
dc.contributor.authorMatsumura, Mai
dc.contributor.authorTakemura, Tamiko
dc.contributor.authorKataoka, Toshiaki
dc.contributor.authorKoike, Chihiro
dc.contributor.authorTateshi, Yoko
dc.contributor.authorTajiri, Michihiko
dc.contributor.authorOgura, Takashi
dc.contributor.authorOhashi, Kenichi
dc.date.accessioned2022-10-24T09:16:03Z
dc.date.available2022-10-24T09:16:03Z
dc.date.issued2019
dc.description.abstractA normal counterpart and precancerous lesion that non-terminal respiratory unit (TRU) lung adenocarcinomas (LADCs) develop from have not been clarified. Non-TRU LADCs specifically express hepatocyte nuclear factor 4α (HNF4α). Thus, we have been interested in airway epithelial cells that express HNF4α as the potential precursor of non-TRU LADC. The purposes of the present study are to report the frequency and distribution of HNF4α-expressing cells at the different airway levels, and to investigate the potential significance of the expression of HNF4α in the histogenesis of non-TRU LADC with a special reference to the relationship to bronchiolar metaplasia in idiopathic interstitial pneumonia. We herein identified a minor subpopulation of epithelial cells that express HNF4α in a physiological state. This subpopulation was mainly located in the terminal bronchioles and had the appearance of ciliated cells, which were mutually exclusive from Clara cells and others that strongly expressed thyroid transcription factor 1. Furthermore, the expression of HNF4α was similar in bronchiolar metaplastic lesions and the terminal bronchioles, and some of the metaplastic lesions showed an unequivocally higher frequency and expression level of HNF4α, which was comparable to non-TRU LADC. In summary, this is the first study to describe a subpopulation of ciliated cells that express HNF4α as a potential normal counterpart for non-TRU LADCs and suggests that bronchiolar metaplastic lesions that strongly express HNF4α are a precancerous lesion for non-TRU LADCs.es
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dc.format.extent11es
dc.identifier.citationHistology and Histopathology Vol. 34, nº 11 (2019)
dc.identifier.doihttps://doi.org/10.14670/HH-18-098
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/124805
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHNF4α expressiones
dc.subjectAirway epitheliaes
dc.subjectBronchiolar metaplasiaes
dc.subjectNon-TRU lung adenocarcinomaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleA subpopulation of airway epithelial cells that express hepatocyte nuclear factor 4α - its implication in the development of non- terminal respiratory unit-type lung adenocarcinoma.es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34,nº11 (2019)