Publication: ACTH-induced ultrastructural changes
in the zona fasciculata of the hamster adrenal cortex.
Are intraadrenal thrombi regulators
of corticosteroid secretion?
Authors
Ginda, Waclaw J. ; Warchol, Jerzy B. ; Malendowicz, L.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Correlated stereological and functional
studies were performed on the effect of massive
ACTH doses on adrenal cortex of the female hamster.
ACTH resulted in a marked increase in adrenal
gland weight at day 6 of treatment followed by a drop
at day 9. Stereology showed significant enlargement of
the zona fasciculata (ZF) cells with the highest value
at day 6 and subsequent drop at day 9 of treatment.
This hypertrophy was due to a notable increase in the
volume of mitochondrial, SER, Golgi apparatus and
lipid droplet compartments. Cortisol secretion by
adrenal slices and homogenates was also highest at day
6 of ACTH administration and notably lower at day 9.
At day 6 of ACTH treatment in outer ZF thrombi
were seen. In their vicinity the subendothelial space
was dilated and endothelial cells dissociated from
the basa1 lamina. Numerous erythrocytes were also
visible among dissociated ZF cells. At day 9 of
experiment in outer part of ZF numerous spaces
devoid of parenchymal cells appeared.
The earlier authors considered the «empty spaces»
or «holes» in hyperstimulated adrenal cortex as-a sign
of holocrine secretion of steroid hormones. The
present findings enable us to introduce a new
hypothesis on the development of these spaces. In our
opinion in hyperstimulated adrenal cortex numerous
thrombi may be formed leading thus to the
degeneration of adrenocortical cells. Thus, the
appearance of the aempty spaces» or «holes» in the
gland is not connected with the holocrine secretion but
with the regulation of the number of secretory cells in
adrenal cortex by the thrombi-dependent mechanism.
A similar mechanism may also be responsible for the
remodelling of the gland after its enlargement due to
ACTH administration.
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