Publication: Gender-related changes in
three-dimensional microstructure of trabecular
bone at the human proximal tibia with aging
Authors
Chen, H. ; Washimi, Yuki ; Kubo, Kin-ya ; Onozuka, Minoru
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Despite increasing interest in age- and
gender-related bone alterations, data on trabecular
microstructure at the proximal tibia are scarce. The aim
of this study was to identify trabecular microstructural
change at the human proximal tibia with age and gender,
using micro-computed tomography (micro-CT) and
scanning electron microscopy (SEM). Fifty-six proximal
tibias from 28 Japanese men and women (57-98 years of
age) were used in this study. The subjects were chosen to
give an even age and gender distribution. Both women
and men were divided into three age groups, middle (57-
68 years), old (72-82 years) and elderly (87-98 years)
groups. The trabecular bone specimens from the medial
compartment of the proximal tibial metaphysis were
examined. Trabecular bone mineral density (BMD),
bone volume fraction (BV/TV) and trabecular thickness
(Tb.Th) decreased between the middle-aged and elderly
groups similarly in women and men. However,
trabecular number (Tb.N) decreased by 13% between the
middle-aged and elderly groups in women and nearly
double that in men. As compared with women, men had
higher BV/TV and lower trabecular separation (Tb.Sp)
in the old age and elderly groups, and higher Tb.N and
connectivity density (Conn.D) in the elderly group.
Increased trabecular resorbing surfaces, perforated or
disconnected trabeculae and microcallus formations
were observed with age. These findings indicate that
both BMD and BV/TV decreased at the proximal tibia
with age similarly for women and men, but significant
differences between women and men were observed for
some microstructural parameters. These findings
illustrate potential mechanisms underlying osteoporotic proximal tibial fracture.
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