Publication: Expression of homeodomain protein CDX2 in colorectal adenoma and adenocarcinoma
Loading...
Date
2008
Authors
Bakaris, Sevgi ; Cetinkaya, Ali ; Ezberci, Fikret ; Ekerbicer, Hasan
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
CDX2 is a homeobox domain-containing
transcription factor that is important in the development
and differentiation of the intestine. In this study, we
examined CDX2 expression in normal and neoplastic
human colon using a newly isolated monoclonal
antibody. When compared to the intensity observed in
adjacent normal mucosal epithelial cells, strong nuclear
staining for CDX2 was observed in 10 (100%) of 10
colonic adenomas, 30 (88.2%) of 34 colorectal
adenocarcinomas, including 17(94.47%) of 18 well-or
moderately differentiated tumors and 13(81.2%) of 16
high-grade tumors. The percentage of CDX2
immunopositive cells was generally lower in carcinomas
than in adenomas (p<0.001) and lower in moderately or
poorly differentiated tumors than in well-differentiated
tumors (p<0.001). There was an inverse correlation
between CDX2 expression and tumor grade, tumor stage
and lymph node metastasis (respectively, p<0.001;
p<0.05; p<0.001), but this was not associated with age,
gender, or tumor location and size. These results indicate
that loss of expression of CDX2 protein may play an
important role in the tumorigenesis of colorectal cancers.
Down-regulation of CDX2 may cause dedifferentiation
of gastrointestinal epithelial cells.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.