Publication: Genetic alterations in pulmonary epithelioid
hemangioendothelioma and epithelioid angiosarcoma
Authors
Cao, Y. ; Zou, S.M. ; Zhang, K.T. ; Lu, N. ; Liu, Y. ; Feng, L. ; Wen, P. ; Han, N.J. ; Lin, D.M.
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Epithelioid hemangioendothelioma (EHE) is
a low-to-intermediate-grade vascular tumor that occurs
in many organs, and epithelioid angiosarcoma (EA) is a
subtype of angiosarcoma that is associated with highgrade
malignancy. These two types of tumors have
different forms of biological behavior. Pulmonary
epithelioid hemangioendothelioma (PEH) and
epithelioid angiosarcoma (PEA) are both very rare, and
genetic studies on them are extremely limited. We
examined and compared the cytogenetic characteristics
of these two types of lung tumors in two patients
utilizing the Array-Comparative Genomic Hybridization
(Array-CGH) method.
Considerable differences in the cytogenetic
characteristics were observed between the two types of
tumors. Small fragment gains (<10 MB) were dominant
in PEH, whereas large fragment gains and deletions (>10
MB) were dominant in PEA. Some large fragment
alterations, such as gains in chromosomes 19q and 19p,
and deletions in chromosomes 9p and 13q, involved over
half of a chromosome arm.
PEH and PEA showed great cytogenetic differences;
therefore, further genetic studies on these two types of
tumors are warranted.
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Citation
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