Publication: Steroid receptors in the testis: implications in the physiology of prenatal and postnatal development and translation to clinical application
Authors
Rey, Rodolfo A.
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-533
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The testes are the main source of sex steroids
in the male, especially androgens and to a lesser extent
estrogens. In target cells, steroid hormones typically
signal after binding to intracellular receptors, which act
as transcription factors. Androgens and estrogens have
ubiquitous functions in peripheral organs, but also have
paracrine actions within the gonads where they are far
more concentrated. The levels of steroid production by
the testes vary throughout fetal and postnatal
development: they are high in intrauterine life and in the
first months after birth, then they decline and are almost
undetectable in childhood and increase again during
puberty to attain adult levels. The expression of the
androgen and estrogen receptors also depict specific
ontogenies in the various testicular cell types. The
combination of intratesticular steroid concentration with
the pattern of expression of the steroid hormone
receptors defines androgen and estrogen action on
Sertoli, germ and Leydig cells. Here, we review the
ontogeny of expression of the androgen and estrogen
receptors in the testis, its impact on testicular physiology
during prenatal and postnatal development, as well as its
implication on the pathophysiology of different disorders
affecting gonadal function throughout life.
publication.page.subject
Citation
Histology and Histopathology, Vol.38, nÂş4, (2023)
item.page.embargo
Ir a EstadĂsticas
Este Ătem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/