Publication: Ferutinin dose-dependent effects on uterus
and mammary gland in ovariectomized rats
Authors
Ferretti, Marzia ; Cavani, Francesco ; Manni, Paola ; Carnevale, Gianluca ; Bertoni, Laura ; Zavatti, Manuela ; Palumbo, Carla
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The present paper completes our recent study
on the effects of phytoestrogen ferutinin in preventing
osteoporosis and demonstrating the superior
osteoprotective effect of a 2 mg/kg/day dose in
ovariectomized (OVX) rats, compared to both estrogens
and lower (0.5, 1 mg/kg/day) ferutinin doses.
Morphological and morphometrical analyses were
performed on the effects of different doses of ferutinin
administrated for one month on uterus and on mammary
gland of Sprague-Dawley OVX rats, evaluated in
comparison with the results for estradiol benzoate. To
verify whether ferutinin provides protection against
uterine and breast cancer, estimations were made of both
the amount of cell proliferation (by Ki-67), and the
occurrence of apoptosis (by TUNEL), two processes that
in unbalanced ratio form the basis for cancer onset. The
results suggest that the effects of ferutinin are dose
dependent and that a 2 mg/kg/day dose might offer a
better protective action against the onset of both breast
and uterine carcinoma compared to ferutinin in lower
doses or estradiol benzoate, increasing cellular apoptosis
in glandular epithelia.
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Citation
Histology and Histopathology, vol. 29, nº 8, (2014)
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