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Expression of matricellular proteins in human uterine leiomyomas and normal myometrium

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dc.contributor.authorBogusiewicz, Michal
dc.contributor.authorSemczuk, Andrzej
dc.contributor.authorJuszczak, Malgorzata
dc.contributor.authorLangner, Ewa
dc.contributor.authorWalczak, Katarzyna
dc.contributor.authorRzeski, Wojciech
dc.contributor.authorTomaszewski, Jacek
dc.contributor.authorRechberger, Tomasz
dc.date.accessioned2017-11-08T17:53:50Z
dc.date.available2017-11-08T17:53:50Z
dc.date.issued2012
dc.description.abstractGrowth of human leiomyomas can probably be initiated as a response to injury, in a way similar to the development of keloids. Among many bioactive molecules, which are implicated in tissue repair, a pivotal role is attributed to matricellular proteins. The aim of the current study was to evaluate the immunohistochemical expression of tenascin-C (TNC), thrombospondin-1 (TSP-1), SPARC/osteonectin and tenascin-X (TNX) in human uterine leiomyomas and normal myometrium. Immunostaining was performed on 33 pairs of paraffin-fixed sections and 9 cell-lines derived from uterine leiomyomas and normal myometrium. Fifteen (45.5%) leiomyomas investigated were positive for TNC, whereas all normal myometrial samples were immunonegative (χ2=19.41; p<0.001). Immunostaining for TSP-1 was observed in 20 (60.6%) uterine fibroids and in 12 (36.4%) control samples (χ2=3.88; p<0.05). The expression of SPARC/osteonectin protein was more frequently found in leiomyomas than in normal myometrium, but this difference was not significant. Apart from one fibroid culture and one myometrial culture, all the others revealed strong TNC immunostaining. Expression of TSP-1 and SPARC/osteonectin was weak to moderate in all established cell-lines. None of the tissues or cell lines investigated showed positive staining for TNX. In conclusion, TSP-1 and TNC are likely to play important roles in the pathogenesis of uterine leiomyomas, presumably affecting cell proliferation and/or extracellular matrix deposition.es
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dc.format.extent8es
dc.identifier.citationHistology and histopathology, Vol. 27, n.º 11 (2012)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/54468
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectUterine leiomyomaes
dc.subjectMatricellular proteinses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::618 - Ginecología. Obstetriciaes
dc.titleExpression of matricellular proteins in human uterine leiomyomas and normal myometriumes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº11 (2012)