Publication: Cell contribution of vasa-vasorum
to early arterial intimal thickening formation
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Date
2007
Authors
Díaz-Flores Jr., L. ; Gutiérrez, Ricardo ; Varela, H. ; Valladares, Francisco ; Díaz-Flores, Lucio ; Madrid Cuevas, Juan Francisco
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In occluded femoral artery segments, intimal
thickening occurred and abundant neovascularization
from the surrounding microcirculation developed. Under
these conditions, the contribution of vasa-vasorum as a
source of supplementary population of cells during the
early intimal thickening formation was studied. Using a
technique that specifically labels venules, predominantly
postcapillary venules, a marker-Monastral Blue B-was
used as a tracer to follow the pericyte, endothelial cell
and monocyte/macrophage lineages. In the first two days
of the experiment, the marker was restricted to the wall
of the periarterial microcirculation, being incorporated
by endothelial cells, pericytes and some
monocytes/macrophages crossing the venule walls.
Later, the marker continues to be observed in some of
the following cells: endothelial cells and pericytes of the
newly-formed vessels, fibroblast-like cells, transitional
cells between pericytes and fibroblast-like cells,
macrophages migrating into the interstitium, myointimal
cells and neoendothelial cells of the arterial lumen.
These findings provide evidence that, during arterial
intimal thickening formation in occluded arterial
segments, the periarterial microvascularization
contributes, in addition to recruited macrophages, newlyformed
endothelial cells and a supplementary population
of fibroblast-like cells and myointimal cells.
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