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The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells

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dc.contributor.authorNandan, Mandayam O.
dc.contributor.authorYang, Vicent W.
dc.date.accessioned2014-01-09T11:39:58Z
dc.date.available2014-01-09T11:39:58Z
dc.date.issued2009
dc.description.abstractThe potential for clinical application of pluripotent embryonic stem cells is immense but hampered by moral and ethical complications. Recent advances in the reprogramming of somatic cells by defined factors to a state that resemble embryonic stem cells have created tremendous excitement in the field. Four factors, Sox2, Oct4, Klf4 and c-Myc, when exogenously introduced into somatic cells, can lead to the formation of induced pluripotent stem (iPS) cells that have the capacity for self-renewal and differentiation into tissues of all three germ layers. In this review, we focus on the role of Krüppel-like factors (KLFs) in regulating somatic cell reprogramming. KLFs are zinc finger-containing transcription factors with diverse biological functions. We first provide an overview of the KLF family of regulatory proteins, paying special attention to the established biological and biochemical functions of KLF4 and KLF5. We then review the role of KLFs in somatic cell reprogramming and delineate the putative mechanism by which KLFs participates the establishment and self-renewal of iPS cells. Further research is likely to provide additional insight into the mechanisms of somatic cell reprogramming and refinement of the technique with which to generate clinically relevant iPS cells.
dc.formatapplication/pdfes
dc.format.extent13es
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/37570
dc.languageenges
dc.publisherMurcia : F. Hernández
dc.relation.ispartofHistology and histopathology
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectSomatic cellses
dc.subjectReprogramminges
dc.subject.other616.3 - Patología del aparato digestivo. Odontología
dc.titleThe role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cellses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24,nº10 (2009)