Publication: Immunohistochemical evidence of lactoferrin in hepatic biopsies of patients
with viral or cryptogenetic chronic liver disease
Authors
Tuccari, G. ; Villari, D. ; Giuffre, G. ; Simone, A. ; Squadrito, G. ; Raimondo, G. ; Barresi, G.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Lactoferrin (Lf) expression has been
immunohistochemically investigated in 117 formalinfixed
paraffin-embedded liver bioptic samples obtained
from an equal number of patients affected by chronic
hepatitis (HCV=76; HBV=17; HBV+HDV=14;
cryptogenetic=10); in addition, 10 autoptic specimens of
normal liver were studied as control. The Lf
immunoreactivity was evaluated by an intensitydistribution
(ID) score. The Lf immunoexpression was
observed in 88 out of 117 (75%) cases of chronic
hepatitis; interestingly, all liver specimens from HBV
hepatitis showed a constant Lf reactivity with the highest
ID-score, whereas the evidence of Lf was encountered in
54/76 (71.1%) HCV as well as in 11/14 (78.6%) HDV
chronic hepatitis, thus documenting a variable degree of
Lf immunostaining in relation to different viruses.
Moreover, in 6/10 (60%) cases of cryptogenetic hepatitis
Lf immunoexpression was documented, whereas all
normal liver controls were unreactive. In HCV
specimens, the Lf nuclear immunoreactivity appeared to
increase with the progression of the disease, with a
greater expression in genotype 1. In contrast, no
relationship among Lf ID-scores and different stages or
grades of HBV, HDV or cryptogenetic hepatitis was
encountered. This fact may suggest a role for Lf as an
unspecific defensive agent in chronic inflammatory liver
diseases, similarly to that elsewhere reported in other
inflammatory tissue injuries.
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