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CD10 is frequently expressed in classical seminomas

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dc.contributor.authorDel Sordo, Rachele
dc.contributor.authorAscani, Stefano
dc.contributor.authorBellezza, Guido
dc.contributor.authorFerri, Ivana
dc.contributor.authorSbaraglia, Marta
dc.contributor.authorSidoni, Angelo
dc.date.accessioned2018-12-13T11:40:59Z
dc.date.available2018-12-13T11:40:59Z
dc.date.issued2014
dc.description.abstractSummary. CD10 is a cell surface metalloproteinase widely expressed in various normal tissue and in epithelial, stromal or both components of various malignancies. The aim of our study was to investigate, for the first time, the expression of CD10 in a series of 135 cases of testicular germ cell tumours in order to asses its possible diagnostic and biologic significance. The expression of CD10 was studied, using immunohistochemistry, in 96 pure forms and 39 mixed forms of germinal cell tumours of the testis. Immunostaining for CD10 was positive in 68/74 (92%) seminomas and 16/24 (67%) seminomatous component of mixed germ cell tumours. The intratubular germ cell neoplasia of the unclassified type always expressed CD10. Anaplastic seminomas, embryonal carcinomas, teratoma and spermatocytic seminomas were negative for CD10. Our findings indicate that only seminomas and intratubular germ cell neoplasia, the precursors of germ cell tumours, express CD10, but when they differentiate along embryonal, somatic, trophoblastic, yolk sac lines they lose CD10 expression. CD10 could be considered a useful marker to differentiate seminoma from other forms of testicular germ cell tumours and for a better estimation of the seminomatous component in mixed germ cell tumours.es
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dc.format.extent6es
dc.identifier.citationHistology and Histopathology, vol. 29, nº 1, (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/65381
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCD10es
dc.subjectSeminomaes
dc.subjectIGCNUes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleCD10 is frequently expressed in classical seminomases
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 1 (2014)