Publication: Histomorphogenesis and immunohistochemical
study of the bovine pineal gland (Bos taurus) during
prenatal development (160 days of gestation to birth)
Authors
Regodón, S. ; Pozo, D. ; Roncero, V.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The ontogenesis of the pineal gland of 20
bovine embryos (Bos taurus) has been analysed from
160 days of gestation to birth by means of optical
microscopy and immunohistochemical techniques. For
this study, the specimens were grouped into two stage in
accordance with the most relevant histological
characteristics: Stage 1 (160 to 200 days of prenatal
development) and Stage 2 (220 days of prenatal
development to birth). At 160 days of gestation some
rounded structures with a central lumen, which we refer
to as glandular rosettes, begin differentiation from the
epithelium of the pineal recess, experiencing an
extraordinary increase in number and size at 200 days of
intrauterine life. In the interior of the pineal parenchyma
we observed some morphologically rounded cells with
oval euchromatic nuclei and a well-differentiated
nucleolus that we refer to as the pinealoblasts. We also
observed other cells characterised by the presence of low
cytoplasm and rounded and highly stained nuclei that we
refer to as the interstitial cells. The glandular stroma is
formed from the capsular, trabecular, and perivascular
connective tissue as well as from the reticular network
that comes from the cellular processes of the interstitial
cells. The blood vessels, at 240 of gestation, show wellformed
walls where the endothelial cells stand out.
At 160 days of gestation we witnessed some cells
with small, dense, oval nuclei, positive to the glial
fibrillary acidic protein (GFAP). At this age NPY
positive fibres were detected, distributed around the
blood vessels and among the pinealoblasts.
We conclude by clarifying that the changes detected
in the morphology as well as in the number and size of
glandular rosettes appear to be related to the functional
activity of the pineal gland during embryonic
development.
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