Publication: Chronic retinal effects by ultraviolet irradiation, with special reference to superoxide dismutases
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Date
1996
Authors
Oguni, M. ; Tamura, H. ; Kato, K. ; Setogawa, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Recently ultraviolet light (UV) reaching the
Earth's surface has been gradually increasing in amounts
by the destruction of the ozone layers. Large parts of UV
are absorbed in the cornea and lens, and only a few
amounts reach the retina; however, the effect on the
retina is not fully elucidated. 38 rats were irradiated 0.5-
5.0 ~ / c mUV~ f rom 6 to 50 times every 24 hours, and
their retinal effects were investigated morphologicaily,
immunohistochemically and immunochemically for
superoxide dismutases (SOD). Morphologically, the
destruction of rod outer segments (ROS) and
dissociation of cell membranes between the pigment
epithelial cells (PE) were already observed by 6 times
0.5 ~ / c mUV~ i rradiations. As the doses of UV
increased, heterochromatins and lipid droplets increased
in the PE. Significant damage was not observed, except
in ROS and PE. In normal retina, CuIZn SOD were
mainly distributed from the inner limiting membrane
(ILM) to the ganglion cell layer, and the PE; however,
after 6 times 0.5 ~ / c mUV~ i rradiations, the distribution
became widened from inner to outer plexiform layer
(OPL). At that time, the concentrations of CuKn and Mn
SOD increased in the retina. The present study reveals
that the morphological damage caused by UV irradiation
is observed in the ROS and PE, where no immunoreactivities
could be detected to CuIZn and Mn SOD.
However, morphological damage was not from the ILM
to OPL, where the imrnunoreactivities to both Cu/Zn and
Mn SOD were observed.
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