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Deconstructing neutrophil to lymphocyte ratio (NLR) in early breast cancer: lack of prognostic utility and biological correlates across tumor subtypes

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dc.contributor.authorGarcía-Torralba, Esmeralda
dc.contributor.authorPérez Ramos, Miguel
dc.contributor.authorIvars Rubio, Alejandra
dc.contributor.authorNavarro Manzano, Esther
dc.contributor.authorBlaya Boluda, Noel
dc.contributor.authorLloret Gil, Miguel
dc.contributor.authorAller, Alberto
dc.contributor.authorMorena Barrio, Pilar de la
dc.contributor.authorGarcía Garre, Elisa
dc.contributor.authorMartínez Díaz, Francisco
dc.contributor.authorGarcía Molina, Francisco
dc.contributor.authorChaves Benito, Asunción
dc.contributor.authorGarcía-Martínez, Elena
dc.contributor.authorAyala de la Peña, Francisco
dc.contributor.departmentOftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
dc.date.accessioned2024-12-12T11:57:45Z
dc.date.available2024-12-12T11:57:45Z
dc.date.issued2024-03-07
dc.description© The Author(s) 2024. This document is the Published version of a Published Work that appeared in final form in Breast Cancer Research and Treatment. To access the final edited and published work see https://doi.org/10.1007/s10549-024-07286-x
dc.description.abstractPurpose The prognostic utility and biological correlates of neutrophil to lymphocyte ratio (NLR), a potential biomarker of the balance between immune response and the inflammatory status, are still uncertain in breast cancer (BC). Methods We analysed a cohort of 959 women with early breast cancer, mostly treated with neoadjuvant or adjuvant chemo therapy. Clinical and pathological data, survival, NLR (continuous and categorical) and stromal tumor infiltrating lympho cytes (sTIL) were evaluated. Results NLR was only weakly associated with Ki67, while no association was found for grade, histology, immunohisto chemical subtype or stage. Lymphocyte infiltration of the tumor did not correlate with NLR (Rho: 0.05, p = 0.30). These results were similar in the whole group and across the different BC subtypes, with no differences in triple negative BC. Relapse free interval (RFI), breast cancer specific survival (BCSS) and overall survival (OS) changed according to pretreatment NLR neither in the univariate nor in the multivariate Cox models (RFI: HR 0.948, p = 0.61; BCSS: HR 0.920, p = 0.57; OS: HR 0.96, p = 0.59). Conclusion These results question the utility of NLR as a prognostic biomarker in early breast cancer and suggest the lack of correlation of NLR with tumor microenvironment immune response.es
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dc.format.extent11es
dc.identifier.citationBreast Cancer Research and Treatment (2024) 205:475–485
dc.identifier.doihttps://doi.org/10.1007/s10549-024-07286-x
dc.identifier.issnPrint: 0167-6806
dc.identifier.issnElectrónic: 1573-7217
dc.identifier.urihttp://hdl.handle.net/10201/147385
dc.languageenges
dc.publisherSpringer
dc.relationThis work was funded by Instituto de Salud Carlos III (Proj ect PI21/380), including FEDER funding by the European Union. ENM was funded by the Ministerio de Educación, Cultura y Deporte (Spain) (FPU16/06537). This work was also partially funded by two research-funding initiatives: “Calasparra se mueve”, a research-funding initiative inspired by women from Calasparra (Murcia), Spain, and by “Pulseras solidarias”, Cieza (Murcia), Spain. The funding sources did not have any role in the collection, analysis, interpretation, writing or the decision to submit.es
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s10549-024-07286-x
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectEarly breast canceres
dc.subjectNeutrophil-to-lymphocyte ratioes
dc.subjectTumor infiltrating lymphocyteses
dc.subjectPrognosises
dc.titleDeconstructing neutrophil to lymphocyte ratio (NLR) in early breast cancer: lack of prognostic utility and biological correlates across tumor subtypeses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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