Publication: Characterization of ligands for
galectins, natural galactoside-binding
immunoglobulin G subfractions and sarcolectin
and also of the expression of calcyclin in thyroid lesions
Loading...
Date
2000
Authors
Nagy, N. ; Decaestecker, C. ; Dong, X. ; Kaltner, H. ; Schuring, M.P. ; Rocman, P. ; Danguy, A. ; Gabius, H.J. ; Kiss, R. ; Salmon, I.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The purpose of this study was to characterize
ligands for galectins, natural galactoside-binding
immunoglobulin G subfractions and sarcolectin and also
the expression of calcyclin in various benign and
malignant thyroid lesions. The extent of the binding of
eight glycochemical probes was quantitatively assessed
using computer-assisted microscopy on 76 thyroid
lesions including 10 not-otherwise-specified
multinodular goiters (S-MNG), 11 multinodular goiters
with adenomatous hyperplasia (AH-MNG), 8
normomacrovesicular (NM-ADE) and 12 microvesicular
(MIC-ADE) adenomas, and 9 papillary (P-CAR), 10
follicular variants of papillary (FvarP-CAR), 7 follicular
(F-CAR) and 9 anaplastic (A-CAR) carcinomas. The 8
histochemical probes included 5 animal lectins
(including galectins and sarcolectin), 1 polyclonal
antibody (raised against calcyclin) and 2 immunoglobulin
G subfractions from human serum with
selectivity to a- and R-galactosyl residues. The results
show that multinodular goiters with adenomatous
hyperplasia exhibited histochemical characteristics
intermediate to those of normal multinodular goiters and
microvesicular adenomas. ~ormomacro~vesicular
adenomas behaved very distinctly from microvesicular
ones. ~ i c r o v e s i c u l aard enomas were more close1 y
related to differentiated thyroid carcinomas than any
other type of benign thyroid lesions of epithelia1 origin.
Papillary and follicular carcinomas seemed to represent
the two extremes of the same biological entity with the
follicular variant of the papillary carcinoma serving as a
biological link between these two extremes. Anaplastic
carcinomas behaved in a significantly different manner
Offprint requests to: Dr. Robert Kiss, Ph.D., Laboratoire
d'Histopathologie, Faculte de Medecine, Un~versiteL ibre de Bruxelles,
808 route de Lennik, 1070 Brussels, Belgium. Fax: 322 555 62 85.
e-mail: rkiss@med.ulb.ac.be
when compared to the differentiated forms of thyroid
carcinomas.
The results suggest that the patterns of expression of
the glycoconjugates investigated in the present study
may constitute useful tools for characterizing lesions in
the human thyroid.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.