Publication: Neurotrophins, airway smooth muscle and the fetal breathing-like movements
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Date
2006
Authors
Inanlou, M.R. ; Baguma-Nibasheka, M. ; Keating, M.M. ; Kablar, B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Central nervous system and skeletal muscles
secrete a group of polypeptide hormones called
neurotrophins (NTs). More recent studies show that NTs
and their receptors are also expressed in the lung,
suggesting a role for NTs in lung development. To
examine the role of NTs during normal and diseased
lung organogenesis, we employed wild-type and
amyogenic mouse embryos (designated as Myf5-/-
:MyoD-/-). Amyogenic embryos completely lacked
skeletal muscles and were not viable after birth due to
the respiratory failure secondary to lung hypoplasia. To
examine the importance of lung-secreted NTs during
normal and hypoplastic lung organogenesis,
immunohistochemistry was employed. Distribution of
NTs and their receptors was indistinguishable between
normal and hypoplastic lungs. To further examine the
importance of non-lung-secreted NTs (e.g., from the
skeletal muscle and CNS) in lung organogenesis, in
utero injections of two NTs were performed. The
exogenously introduced NTs (i.e., non-lung-secreted) did
not appear to improve development of the lung in
amyogenic embryos. Moreover, immunohistochemistry
showed significantly reduced number of airway smooth
muscle cells (ASMCs) in hypoplastic lungs of
amyogenic embryos, suggesting that the number of
ASMCs is primarily regulated by the fetal breathing-like
movements (i.e., mechanical factors).
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