Publication:
Alteration of primate ovary surface epithelium by exposure to hexachlorobenzene: A quantitative study

Repository logo
Date
1991
relationships.isAuthorOfPublication
relationships.isSecondaryAuthorOf
relationships.isDirectorOf
Authors
Sims, David E. ; Singh, Amreek ; Donald, Alan ; Jarrell, John ; Villeneuve, David C.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Hexachlorobenzene (HCB) is a fungicide and a pollutant of increasing concern in industrialized regions of the world. Reproductive failure is one of the effects of HCB upon mammals. Alteration of cell shape in the ovary surface epithelium (OSE) of Cynomolgus monkeys following oral administration of HCB was observed in this study. At the lowest dose used, 0.1 mgl kg body weight, a dosage that is associated with follicular degeneration, HCB caused quantifiable changes in length-to-width ratios of OSE. Measurement of cell shape by light microscopy offers a reliable indication of OSE changes induced by HCB.
publication.page.subject
Monkey ovary , Hexachlorobenzene
Citation
URI
http://hdl.handle.net/10201/18272
item.page.embargo
Collections
Histology and histopathology Vol. 6, nº 4 (1991)
Ir a Estadísticas