Publication: Dorsal skin responses to
subchronic ultraviolet B (UVB)-irradiation in
Wistar-derived hypotrichotic WBN/ILA-Ht rats
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Date
2002
Authors
Malcotti, V. ; Yasoshima, A. ; Imaoka, K. ; Nakayama, Hiroyuki ; Doi, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Dorsal skin responses to a subchronic UVBirradiation
(10kJ/m2/rat /day), were examined in Wistarderived
hypotrichotic WBN/ILA-Ht rats for up to 3
months. Hyperplasia of epidermal cells and hair follicle
epithelial cells as well as parakeratosis developed at 1
month and progressed thereafter, resulting in a
prominent epidermis thickening and formation of
epidermal ingrowths projecting into the dermis. At the
same time, the percentage of proliferating cell nuclear
antigen (PCNA)-positive epidermal cells significantly
increased after 1 month. In some portions of the
hyperplastic epidermis, especially of the epidermal
ingrowths, keratinocytes were somewhat pleomorphic
and migrated into the dermis. In the upper dermis,
edema with capillary congestion, mast cell infiltration
and fibroblast proliferation developed at 1 month, and
the intensity of edema and the number of dermal mast
cells was most prominent at 3 months. Edema spread to
the epidermis, resulting in intercellular edema and
subsequent dissociation of epidermal cells. Degeneration
of collagen fibers was also detected in the upper dermis,
especially beneath the epidermis. In addition, although
not significant because of a large individual difference,
the serum IgE concentration, showed a tendency to
increase after 2 months. The present study clarified the
characteristics of the dorsal skin responses to a
subchronic UVB-irradiation in rats.
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