Publication: PiRNAs link epigenetic modifications to reprogramming
Authors
Wang, Yin ; Sun, Teng ; Wang, Kun ; Wang, Jian-Xun ; Li, Pei-Feng
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-29.1489
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info:eu-repo/semantics/article
Description
Abstract
Cell reprogramming is a process involved in
changing epigenetic landscapes, including histone
modification, DNA methylation, and expression of noncoding
RNAs; and reprogramming finally leads to
changes in gene expression profile and cell fate. A great
challenge to this field is to overcome epigenetic
suppression exerted by highly differentiated cells of
those key regions that are critical for establishment and
maintenance of final cell types or induced pluripotent
stem cells (iPSCs). As a new class of small non-coding
RNAs, piwi-interacting RNAs (piRNAs) have been
shown to play important roles in transposon silencing,
transcriptional/post-transcriptional regulation, and
epigenetic modifications. In this review, we discuss
recent advances in which piRNAs were proposed or
shown to be barriers to reprogramming suppression
through epigenetic silencing, and it may be necessary to
overcome this piRNA-derived barrier to achieve final
cellular status during reprogramming. Therefore, gaining
deeper insights into the mechanism(s) by which piRNAs
mediate epigenetic regulation of gene expression,
genome stability and chromatin status may offer a new
avenue for efficient reprogramming of somatic cells
toward a pluripotent state.
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Citation
Histology and Histopathology, Vol. 29, n.º 12 (2014)
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