Publication: Expression of Raf Kinase Inhibitor Protein (RKIP)
is a predictor of uveal melanoma metastasis
Authors
Caltabiano, Rosario ; Puzzo, Lidia ; Barresi, Valeria ; Cardile, Venera ; Loreto, Carla ; Ragusa, Marco ; Russo, Andrea ; Reibaldi, Michele ; Longo, Antonio
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Melanoma arising from melanocytes within
the choroid is the most frequent primary intraocular
neoplasm in adults. It is biologically distinct from
cutaneous melanoma by a very strong propensity to
metastasize the liver. Raf kinase inhibitor protein is a
member of an evolutionarily conserved group of proteins
called phosphatidylethanolamine-binding proteins. It is
an interacting partner of Raf-1 and a negative regulator
of the mitogen-activated protein kinase cascade initiated
by Raf-1. Raf kinase inhibitor protein expression is low
in many human cancers and represents an indicator of
poor prognosis and/or induction of metastasis. In the
present study, we examined the immunohistochemical
expression levels of Raf kinase inhibitor protein and
phosphorylated Raf kinase inhibitor protein in primary
uveal melanoma with and without metastasis, and
evaluated their association with other high risk
characteristics for metastasis in order to assess whether
Raf kinase inhibitor protein and phosphorylated Raf
kinase inhibitor protein can be used to predict
metastasis. A significant low expression of Raf kinase
inhibitor protein was seen in patients with metastasis but
not in patients without metastasis. The latter more
frequently had a high expression of Raf kinase inhibitor
protein. No significant difference was seen in
phosphorylated Raf kinase inhibitor protein expression
between patients with and without metastasis. Raf kinase
inhibitor protein expression is a suitable and easily
determinable marker in the primary tumour that could
predict the risk of uveal melanoma to metastasize, and
hence guide strategies for monitoring and therapy.
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Citation
Histology and Histopathology, vol. 29, nº 10, (2014)
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